The Benefits of Inositol Supplementation for PCOS
Inositol, a naturally occurring sugar found in the body and various foods, including citrus fruits and cereals, offers a promising approach to managing PCOS symptoms.
What is Inositol?
Inositol plays a key role in cellular processes, including insulin signaling, which is crucial for blood sugar management—a critical factor in addressing PCOS.
There are nine types of inositol, but Myo-inositol (MI) and D-chiro-inositol (DCI) are particularly relevant for PCOS.
Myo-Inositol (MI): Supports hormonal signaling in the ovaries.
D-chiro-Inositol (DCI): Aids in testosterone synthesis.
Women with PCOS often experience an imbalance in the MI to DCI ratio. High insulin levels, common in PCOS, can alter this ratio, leading to increased androgens and reduced inositol effectiveness.
Potential Benefits of Supplementing
Insulin Sensitivity: Inositol may enhance insulin sensitivity.
Improved Ovarian Function: May improve ovarian function and egg quality, potentially boosting fertility.
Symptom Reduction: Linked to reduced symptoms like acne, excessive hair growth, and weight gain through better hormonal balance.
Hormonal Balance: May help normalize luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels, essential for regular menstrual cycles.
How to Take Inositol
Inositol is available in powder or capsule form. A 40:1 ratio of Myo-Inositol to D-chiro-inositol is often recommended for PCOS. My favorite brand is Ovasitol, which is in powder form. Because inositol is sweet, it is highly tolerable and can even spruce up food and beverages. I like to add it to water, matcha, coffee, or smoothies. The typical dose is 2 to 4 grams per day, or one scoop twice a day, taken with meals.
Who is this Not For?
Inositol therapy is most suitable for those with high androgens or insulin resistance. If you have PCOS and do not have high androgens or insulin resistance, this may not be the most suitable for you. Be cautious if you are on medication for blood sugar management, as it might cause levels to drop too low. Consult your healthcare provider if you are pregnant or breastfeeding before starting inositol.
Potential Side Effects
Inositol is generally safe, with minimal side effects. Some may experience mild digestive symptoms, such as nausea or diarrhea, especially at the start. It's best to begin with a lower dose and gradually increase.
Always consult your healthcare provider to ensure it’s the right choice for you.
References
Kalra B, Kalra S, Sharma JB. The inositols and polycystic ovary syndrome. Indian J Endocrinol Metab.2016;20(5):720-724. doi:10.4103/2230-8210.189231
Carlomagno G, Unfer V, Roseff S. The D-chiro-inositol paradox in the ovary. Fertil Steril. 2011;95:2515–6.
Laganà A.S., Garzon S., Casarin J., Franchi M., Ghezzi F. Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends Endocrinol. Metab. 2018;29:768–780. doi:10.1016/j.tem.2018.09.001.
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